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Evolence®  Dermal Filler




Photo Source Evolence


Ask about Evolence mail-in rebates from the manufacturer. Up to $150. Call for details.
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Evolence ® dermal filler - A New Longer Lasting "No to Low Bruise" Collagen Dermal Filler


Evolence ® is a next generation collagen filler with natural cross linking and immediate effect. The product provides several benefits for injection correction of wrinkles:

  • highest level of bruise avoidance
  • most minimal of post injection swelling-
  • double the duration of previous collagens with an FDA indication of up to 12 months
  • no collagen pre-testing

One of the primary benefits of natural collagen is the minimal post injection side effects such as bruising and swelling. The earlier collagens such as Cosmoderm, Cosmoplast and the original Zyderm collagens work great, but only for a few months.

No pretesting - Zyderm and Zyplast bovine collagen required pre-testing and patients had to wait weeks to see if they "passed" the allergy sensitivity tests. Once a decision has been made to use a filler, most patients don't want to wait for testing. There is no waiting with Evolence ® dermal filler.

Patients also demanded more longevity for their injection dollar. The response from the dermatology industry was the hyaluronic acid fillers such as Restylane and Juvederm. The tradeoff  with the HA fillers has been some swelling and along with that an increase in potential bruising. With effects lasting up to 12 months, Evolence ® has become a popular dermal filler for those who prefer the instant structural support of collagen. (More about the differences below)

With the development and FDA approval of Evolence, collagen has once again re-entered the filler market. Derived from porcine sources, it may not be a selection for everyone, but for the broad market, Evolence is a great addition to the available choices.

Evolence has been used in Canada, Europe and other countries since 2004 and has a proven safety and duration record with effects lasting 6 to 12 months.


How is Evolence different from Hyaluronic Acid Fillers?

Dermal fillers that use hyaluronic acid (HA) absorb water and hold water to create their effect. So from the perspective of action, HAs are collagen substitutes and Evolence is a collagen replacement.

Evolence is a true structural agent that utilizes a three-dimensional collagen matrix. The primary hyaluronic gels like Juvederm, Restylane and Perlane all work very well to smooth wrinkles and fill deep lines and folds. The choice of fillers is a matter of preference because the end result is the same.

What is the upside of Evolence?

This collagen structure benefits patients as it is directly linked to the minimal bruising and swelling that might result. EVOLENCE® does not use chemicals for cross-linking like many other products do, but instead uses natural sugar to improve durability. The duration of Evolence is very similar to the hyaluronic gels.

What is the downside of Evolence?

Really, the only possible "downside" for some may be the source of Evolence. Because Evolence is derived from porcine sources, some will prefer to stick with the hyaluronic gels which are not sourced from animals. The same collagen sources for Evolence have been used for many years to replace heart valves since the tissue compatibility with humans is so high.

Anything else I need to know about Evolence?

Yes. Evolence requires skilled injection technique. Make sure your physician or injection nurse has been STAR certified. Dr. Pilest has close to 3 decades as an injection specialist and is a trainer for Radiesse, Juvederm and Botox and is of course an EVOLENCE® STAR™ trained physician.



View the Evolence Website for Photos and more Information

Safety and Patient Information

Dr. Pilest is an independent health care professional whose services are not sponsored, licensed, recommended, or endorsed, or in any manner supervised by, affiliated with or related to Ortho Dermatologics

Related Dermal Fillers

Juvederm for lips, wrinkles and folds
Restylane for wrinkles, folds, under-eye hollows, earlobe lift
Radiesse for nasolabial folds, nose correction, cheek and chin augmentation and hand rejuvenation




2009 © Total Dermatology is one of Southern California's top laser dermatology centers offering laser treatments for sundamage, pigmentation, acne and acne scars and Fraxel CO2 laser for 3 in 1 skin rejuvenation. A Nonsurgical Nose Job is possible with simple injections of Radiesse. Dr. Pilest, a Board Certified dermatologist and one of Orange County's most popular cosmetic dermatology specialists, offers patients in Orange County a wide variety of wrinkle fillers such as Restylane, Juvederm, Cosmoderm and Cosmoplast, Radiesse (also known as Radiance), and Sculptra. Dr. Pilest treats patients from the Newport Beach, Irvine, Laguna Beach, Laguna Hills, Tustin, Mission Viejo and Orange County area as well as cities throughout California, the United States and abroad. He is recognized as a master level injection specialist and is a national teaching faculty member for Bioform Medical. Dr. Pilest is well known for his expert treatments in managing Rosacea, acne, and hyperpigmentation.

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