JUVÉDERM
The ‘Next Generation’ in Hyaluronic Acid Dermal Fillers

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JUVÉDERM™ dermal filler, a ‘next generation’ hyaluronic acid dermal filler approved by the FDA in June 2006, contains the highest concentration of cross-linked hyaluronic acid of any dermal filler currently available. These attributes provide optimal results with a single treatment of JUVÉDERM™ in the majority of patients and deliver sustained results for up to six months or longer.

New Study Results : At 24 weeks, 96 percent of nasolabial folds treated with Juvederm had maintained clinically significant correction, and 81 percent maintained the correction for 1 year or more. Results were similar for those subjects with follow-up through 48 weeks after repeated treatment. The median volume required for repeated treatment with Juvederm was significantly less than that for initial treatment (0.7 ml versus 1.6 ml). Article from Jan 2008 American Society of Plastic Surgeons Journal

In addition, JUVÉDERM™ dermal filler is the only hyaluronic acid dermal filler developed using a proprietary, technologically advanced manufacturing process that results in a malleable smooth gel that flows easily into the skin, creating a smooth, natural look and feel. All other currently approved hyaluronic acid dermal fillers utilize a gel particle suspension formulation.

Hyaluronic Acid Animation

JUVÉDERM™ dermal filler can be administered in a smooth-flowing injection, providing physicians with a high level of control for individualized, tailored facial contouring and for achieving a smooth and natural look.

Source LeaDerm

Juvederm is an excellent treatment option for:

• Lip enhancement

• Deep folds

• Facial lines

• Wrinkle correction

• Volume augmentation of the lips

• Shaping facial contours (such as cheeks and chin correcting)

• Smile lines (correcting thin, superficial lines around the eyes, mouth and forehead)

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Visit the Juvederm Website for more photos, facial assessment tools and special Benefits Program

A special advantage of Juvederm wrinkle filler is the Three Levels (two are now available) of product formulation which provide solutions for deep folds and lines, moderate wrinkling and the fine lines found around the lips and eyes.

The three product formulations include:

− JUVÉDERM™ dermal filler Ultra, a highly cross-linked formulation for more versatility in contouring and volumizing of facial wrinkles and folds;

− JUVÉDERM™ dermal filler Ultra Plus, a more highly cross-linked robust formulation for volumizing and correction of deeper folds and wrinkles; and

− JUVÉDERM™ dermal filler 30, a highly cross-linked formulation for subtle correction of fine facial wrinkles and folds (Not yet available in U.S.).

Juvederm has been used in Europe since 2000 and in Canada since 2002. Juvederm® products are currently approved or registered in over 36 countries, including all major European markets.

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Before	After

Hyaluronic Acid Background

Physicians have been developing ways to restore volume and structure to aging skin using a variety of approaches for over 100 years. Past fillers included paraffin, silicone and collagen injections.

In the 1930s, researchers discovered a natural substance in the body that they named hyaluronic acid, and they found that it plays a key role in numerous areas of the body including the maintenance of skin volume and hydration, eye volume and shape and joint lubrication and cushioning.

In the decades since, numerous therapeutic and aesthetic uses have been developed for this versatile natural substance. In 2003, the U.S. Food and Drug Administration (FDA) approved the first hyaluronic acid dermal filler for the correction of facial wrinkles and folds, such as nasolabial folds (the folds running from the sides of the bottom of the nose to the outer corners of the mouth).

Today, hyaluronic acid-based dermal fillers are the fastest growing non-invasive aesthetic procedure in the United States, according to the American Society for Aesthetic Plastic Surgery.1

What is hyaluronic acid?

Hyaluronic acid is a natural complex sugar found throughout all living organisms that retains water -- absorbing more than 1,000 times its weight -- and adds volume to the skin’s surface. In addition, hyaluronic acid binds with collagen and elastin and transports essential nutrients to these fibers. The triple combination of collagen, elastin and hyaluronic acid provides structure, elasticity and volume to the skin and contributes to its overall appearance.

As the skin ages and is exposed to environmental pollutants and ultraviolet rays, the cells lose the ability to produce hyaluronic acid. As a result, the skin begins to lose volume, often resulting in the formation of facial wrinkles and folds. Dermal fillers compromised of crossed-linked hyaluronic acid are used by physicians to help temporarily replace lost hyaluronic acid and to restore skin volume and a smooth, natural appearance.

What is cross-linked hyaluronic acid?

In its natural form, unbound hyaluronic acid forms a liquid made of highly-hydrated individual polymers (chains) that are metabolized in the body in just 12 hours. Cross-linking refers to a process in which the individual chains of hyaluronic acid are chemically bound (or “cross-linked”) together, transforming the liquid hyaluronic acid into a soft solid, or “gel.” The firmness of the gel depends on the degree of cross-linking of the individual hyaluronic acid chains. The body metabolizes cross-linked hyaluronic acid more slowly, resulting in a longer duration of effect when hyaluronic acid is used therapeutically.

1 American Society for Aesthetic Plastic Surgery. February 24, 2006

Safety Information

Photo Source LeaDerm

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